The program features a panel of three public figures, answering questions issues that affect people every day involving political correctness, personal values and the unending capacity to make life complicated. The program is recorded live in front of a studio audience and broadcast on the following night. The show is produced by Andrew Denton and Zapruder’s Other Films.

On 23 October 2012 Can of Worms was renewed for a third series that would be broadcast around the nation live.